Conditioning regimens for ALL allografts
نویسندگان
چکیده
منابع مشابه
Conditioning regimens for hematopoietic cell transplantation: one size does not fit all.
An essential component of allogeneic and autologous hematopoietic cell transplantation (HCT) is the conditioning regimen administered before the hematopoietic cell infusion. Early regimens relied on dose intensity, assuming that high-dose chemoradiotherapy would eliminate malignant disease and reinfusion of the graft would then restore hematopoiesis. However, as the contribution of graft-versus...
متن کاملReview Series ADVANCES IN HEMATOPOIETIC CELL TRANSPLANTATION Conditioning regimens for hematopoietic cell transplantation: one size does not fit all
Hematopoietic cell transplantation (HCT) is a potentially curative therapeutic approach for a variety of malignant and nonmalignant hematopoietic diseases. When HCT is performed in patients with malignant disorders, preparative or conditioning regimens are administered as part of the procedure to achieve 2 goals: provide sufficient immunoablation to prevent graft rejection and reduce the tumor ...
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RATIONALE A better understanding of the composition of optimal treatment regimens for multidrug-resistant tuberculosis (MDR-TB) is essential for expanding universal access to effective treatment and for developing new therapies for MDR-TB. Analysis of observational data may inform the definition of an optimized regimen. OBJECTIVES This study assessed the impact of an aggressive regimen-one co...
متن کاملReduced-intensity conditioning regimens in malignant haematological diseases.
Allogeneic stem cell transplantation is a potentially curative procedure for patients with haematological malignancies. Conventional, myeloablative conditioning is, however, poorly tolerated by patients of advanced age, those receiving second transplants and those with concomitant diseases. Based on recognition of the importance of a graft-versus-disease (GVD) effect in curing malignant haemato...
متن کاملConditioning regimens for allotransplants for diffuse large B-cell lymphoma: myeloablative or reduced intensity?
The best conditioning regimen before allogeneic transplantation for high-risk diffuse large B-cell lymphoma (DLBCL) remains to be clarified. We analyzed data from 396 recipients of allotransplants for DLBCL receiving myeloablative (MAC; n = 165), reduced intensity (RIC; n = 143), or nonmyeloablative conditioning (NMAC; n = 88) regimens. Acute and chronic GVHD rates were similar across the group...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2007
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1705596